If you do not yet have an account, use the button below to register. After reconstitution, the edexÂ® injection device is used to administer the intracavernous injection of alprostadil. If bleeding continues or recurs after applying pressure, abstain from intercourse. Erectile Dysfunction of Pure Neurogenic Etiology (Spinal Cord Injury): Dosage titration should be initiated at 1.25 mcg of alprostadil. EDEX- alprostadilÂ injection, powder, lyophilized, for solutionÂ Endo Pharmaceuticals, Inc. Sterile Powder and Diluent(sterile 0.9% sodium chloride) in Cartridges. Remove the seal from the base of the needle. The plunger is used to force the sterile 0.9% sodium chloride (1.075 mL) in one chamber into the chamber containing alprostadil. 4) After injection of the edexÂ® solution, compression of the injection site for five minutes, or until bleeding stops, is necessary. However, there is no need to compile it, since its maintainers offer an executable file for Windows 10. Tom-slick. Tell your doctor if you have a condition or are taking a medicine that interferes with blood clotting. How to install and use eDEX-UI. The default terminal type is xterm-color, meaning it has full-color support. 2 comments. Even if you previously took the course with Python 2.7, you will be able to easily transition to Python 3.5 in future courses, or enroll now to refresh your learning. edexÂ® Cartridge 2 Pack contains enough supplies for two injections. Alprostadil had a significant effect on the pharmacodynamics of heparin resulting in a 140% increase in partial thromboplastin time and a 120% increase in thrombin time. The edexÂ® cartridge contains a solid layer or lyophilized cake of dry white powder approximately 3/8" in thickness. After reconstitution, the edexÂ® injection device is used to administer the intracavernous injection of alprostadil. Mine does not have it but I wasn’t sure if you can buy an adaptor so to speak? 3 months), is strongly recommended to identify any penile changes. Therefore, the use of such combinations is not recommended. The dose of edexÂ® that is selected for self-injection treatment should provide the patient with an erection that is satisfactory for sexual intercourse and that is maintained for no longer than 1 hour. This leaflet provides a summary of information about your medicine. If you want to restrict what eDEX-UI can do on your system, you can run the AppImage in a sandbox like Firejail. Alprostadil is a smooth muscle relaxant. 2020-11-20 Set Appimage compression rate to normal Appimage construction used to compress files aggressively. In a study in symptomatic subjects with end-stage renal disease undergoing hemodialysis and age/weight/sex-matched healthy volunteers, 120 mcg of alprostadil was administered by intravenous infusion over 2 hours. At that time, the efficacy and safety of the therapy should be assessed, and the dose of edexÂ® should be adjusted, if needed. The other four tabs (labeled EMPTY) don't have anything loaded and will start a shell when you click on one. Limited data are available in regard to edexÂ® overdose in humans. After the boot, eDEX-UI shows system information, a file browser, a keyboard (for tablets), and the main terminal tab. The empirical formula of Î±-cyclodextrin is C36H60O30 and the molecular weight is 972.85. Do not add any drugs or solutions to the edexÂ® solution. I draw out 10mcg from a separate syringe, Idea is to have remaining 10mcg. After intracavernous administration in monkeys, radiolabeled Î±-cyclodextrin was rapidly distributed from the injection site with less than 0.1% of the dose remaining in the penis 1 hour after administration. In connection to using Edex. Among the 60% (139/233) of patients who entered the open-label treatment phase, the mean rate of response with an erection sufficient for intercourse was 85.3% through six months. HOW SUPPLIED 1. Alprostadil is used only when needed. edexÂ® (alprostadil for injection) is a sterile, pyrogen-free powder containing alprostadil in an alfadex (Î±-cyclodextrin) inclusion complex. Do not... 3. Carefully follow the instructions for administration which are described below. If the dosage prescribed is less than 1 mL of edexÂ® solution, excess solution will be expelled through the needle as the plunger is pushed and the upper rim of the top stopper reaches the correct volume mark for the prescribed dose. As with all prescription medicines, the patient should not allow anyone else to use his medicine. Do not touch the tip of the cartridge after it has been cleansed with the alcohol swab (Figure E). Stream Tracks and Playlists from EDEX on your desktop or mobile device. The file browser does everything you'd expect, including opening associated applications when you click on a file. Before using Edex. In most cases, these reactions were attributed to faulty injection technique. The plunger is used to force the sterile 0.9% sodium chloride (1.075 mL) in one chamber into the chamber containing alprostadil. This is especially true for the initial self-injections, since adjustments in the dose of edexÂ® may be needed. To minimize the chances of prolonged erection or priapism, edexÂ® should be titrated slowly to the lowest effective dose (see DOSAGE AND ADMINISTRATION). Is that really what you want, though? PGE1 entering the systemic circulation is rapidly and extensively metabolized in the lungs with a first-pass pulmonary elimination of 60 to 90% of PGE1. Download: eDEX-UI Terminal Emulator. Erectile response was measured by the Buckling Test to assess axial penile rigidity. The frequency of penile pain reports decreased over time; 41% of the patients experienced pain during the first 2 months and 3% of the patients experienced pain during months 21-24. Go to the Releases tab, or download it through one of the available repositories. EDEX. If the cartridge is damaged, the cake may shrink in size. This run features lecture videos, lecture exercises, and problem sets using Python 3.5. Do not try to straighten a bent needle. Before using, check this product visually for particles or discoloration. Inform your doctor if your condition persists or worsens (for example, if the drug does not produce an erection or it becomes more difficult to get an erection). At-Home (Maintenance Therapy) Dosing Instructions. (Also, see Drug-Drug Interactions in CLINICAL PHARMACOLOGY, Pharmacokinetics.). Use eDEX-UI to give your PC UX a cool TRON or Sci-FI look. A normal cake may appear cracked or crumbled. Some of these conditions include sickle cell anemia or trait, leukemia, and tumor of the bone marrow (multiple myeloma). This medicine helps to create and maintain an erection. The chemical name for alprostadil is (1R,2R,3R)-3-Hydroxy-2-[(E)-(3S)-3-hydroxy-1-octenyl]-5-oxocyclopentane heptanoic acid. Please read this information carefully before you prepare the edexÂ® solution. Beginning with a 40 mcg bolus intravenous dose, the frequency of drug-related systemic adverse events increased in a dose-dependent manner, characterized mainly by facial flushing. Patients should be instructed to report to the physician any penile redness, swelling, tenderness or curvature of the erect penis. You can use eDex to manage and quickly search lists of patients (active, inactive, or archived), employers, insurance carriers, labs, non-patients, providers, staff, referrals, and any other contact you may want to remember. The needle must be properly discarded after use; it must not be reused or shared with other persons. 4 Replies. Sandboxing eDEX-UI. In the majority of cases, spontaneous detumescence occurred. How is Edex Injection Supplied 1. The single-dose, dual-chamber cartridge should be reconstituted only when it is certain that the patient is ready to administer the drug. Using the edX Mobile App. On a tablet, eDEX-UI gives me that cyberspace feel without impacting my productivity. 10. After reconstitution, PGE1 immediately dissociates from the Î±-cyclodextrin inclusion complex; the in vivo disposition of both components occurs independently after administration. 18. Patients should be aware of possible side effects of therapy with edexÂ®; the most frequently occurring is penile pain during and/or after injection, usually mild to moderate in severity. 6. 20. That way the only thing you can use is that application. No unchanged PGE1 has been found in the urine and there is no evidence of tissue retention of PGE1 and its metabolites. Themes are also stored in the configuration directory and, since they are also JSON files, creating a custom theme is pretty straightforward. It runs in full screen with sidebars and bottom panels to monitor system and networks stats. We recommend an i5 or i7 processor and at least 8GB of RAM. Ideally, the injection should be administered just prior to foreplay. The user should be instructed in the proper disposal of the needles and cartridges. Remove the seal from the base of the needle. Seventy-six percent (87/114) of patients had an erection with a positive penile Buckling Test. Alprostadil (PGE1) is one of the prostaglandins, a family of naturally occurring acidic lipids with various pharmacological effects. The pharmacokinetic and pharmacodynamic interaction between alprostadil intravenous infusion, 90 mcg over 3 hours, and heparin (5,000 IU) was evaluated in 12 healthy volunteers. Medicare coverage and pricing details for Edex. To the Patient: By using the edex ® Savings Card (the “Card”), you are certifying that you meet the eligibility criteria and understand and will comply with the Terms and Conditions listed below. eDEX-UI is a cross-platform terminal program designed for tablets and desktops that was inspired by the user interface in Tron. To prevent bruising, apply firm pressure at the injection site for 5 minutes; continue until bleeding stops. It doesn't have to be that way. The reusable edex® injection device is for use only with the cartridges and needles included in the edex® Cartridge Packs. Once the injection device is dry, place it in the carrying case. Be initiated at 1.25 mcg of alprostadil dysfunction is often due to small air bubbles for tissue hypoxia possible... 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